1: With sodium hydroxide in N,N-dimethyl acetamide T=50°C; 4 h; 2: With phosphoric acid in N,N-dimethyl acetamide; water T=20°C; pH=Ca. 5;

1.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C 1.2: pH Ca. 3 - 3.5 2.1: N,N-dimethyl acetamide / 1 h / 20 °C 3.1: N,N-dimethyl acetamide / 6 h / 50 °C 4.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C 4.2: 20 °C / pH Ca. 5 View Scheme

1.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 95 - 97 °C 2.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C 2.2: pH Ca. 3 - 3.5 3.1: N,N-dimethyl acetamide / 1 h / 20 °C 4.1: N,N-dimethyl acetamide / 6 h / 50 °C 5.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C 5.2: 20 °C / pH Ca. 5 View Scheme

1.1: N,N-dimethyl acetamide / 1 h / 20 °C 2.1: N,N-dimethyl acetamide / 6 h / 50 °C 3.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C 3.2: 20 °C / pH Ca. 5 View Scheme

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 - 8 °C 1.2: 1.33 h / 3 - 20 °C 2.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 95 - 97 °C 3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C 3.2: pH Ca. 3 - 3.5 4.1: N,N-dimethyl acetamide / 1 h / 20 °C 5.1: N,N-dimethyl acetamide / 6 h / 50 °C 6.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C 6.2: 20 °C / pH Ca. 5 View Scheme

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 0 - 8 °C 1.2: 1.33 h / 3 - 20 °C 2.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 95 - 97 °C 3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 20 °C 3.2: pH Ca. 3 - 3.5 4.1: N,N-dimethyl acetamide / 1 h / 20 °C 5.1: N,N-dimethyl acetamide / 6 h / 50 °C 6.1: sodium hydroxide / N,N-dimethyl acetamide / 4 h / 50 °C 6.2: 20 °C / pH Ca. 5 View Scheme

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