7,8-二甲氧基-2,3,4,5-四氢-2-苯并氮杂卓合成路线 （共 8 条）
反应条件
diborane in tetrahydrofuran 15 h; Heating;
参考文献
Walpole, Christopher S. J.; Bevan, Stuart; Bovermann, Guenter; Boelsterli, Johann J.; Breckenridge, Robin; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 1942 - 1954
反应条件
sodium hydroxide in ethanol; water 1 h; Heating;
参考文献
Horiguchi, Yoshie; Saitoh, Toshiaki; Terakado, Sachiko; Honda, Konomi; Kimura, Tomoko; Toda, Jun; Sano, Takehiro
Heterocycles, 2001 , vol. 54, # 2 p. 967 - 984
反应条件
1.1: acetic acid / ethanol / 23 h / Heating 1.2: 74 percent / NaBH4 / ethanol / 0.5 h / 0 - 20 °C 2.1: 100 percent / Ac2O / 1 h / 70 °C 3.1: 84 percent / NaIO4 / H2O; methanol / 5 h / 20 °C 4.1: 56 percent / TFAA / benzene / 4 h / 20 °C 5.1: 80 percent / NiCl*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.33 h / 0 °C 6.1: 98 percent / NaOH / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 54, # 2 p. 967 - 984
反应条件
1: 100 percent / Ac2O / 1 h / 70 °C 2: 84 percent / NaIO4 / H2O; methanol / 5 h / 20 °C 3: 56 percent / TFAA / benzene / 4 h / 20 °C 4: 80 percent / NiCl*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.33 h / 0 °C 5: 98 percent / NaOH / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 54, # 2 p. 967 - 984
反应条件
1: 84 percent / NaIO4 / H2O; methanol / 5 h / 20 °C 2: 56 percent / TFAA / benzene / 4 h / 20 °C 3: 80 percent / NiCl*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.33 h / 0 °C 4: 98 percent / NaOH / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 54, # 2 p. 967 - 984
反应条件
1: 56 percent / TFAA / benzene / 4 h / 20 °C 2: 80 percent / NiCl*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.33 h / 0 °C 3: 98 percent / NaOH / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 54, # 2 p. 967 - 984
反应条件
1: hydrogenchloride; sodium azide 2: lithium aluminium tetrahydride / tetrahydrofuran View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 6 p. 1852 - 1859
反应条件
1: 80 percent / NiCl*6H2O; NaBH4 / methanol; tetrahydrofuran / 0.33 h / 0 °C 2: 98 percent / NaOH / ethanol; H2O / 1 h / Heating View Scheme
参考文献
Heterocycles, , vol. 54, # 2 p. 967 - 984
