4-(4-氧代-3,4-二氢喹唑啉-2-基)丁酸合成路线 （共 7 条）
反应条件
urea hydrogen peroxide addition compound; potassium carbonate in water; acetone T=80°C; 22 h;
参考文献
Lindgren, Anders E.G.; Karlberg, Tobias; Ekblad, Torun; Spjut, Sara; Thorsell, Ann-Gerd; Andersson, C. David; Nhan, Ton Tong; Hellsten, Victor; Weigelt, Johan; Linusson, Anna; Schueler, Herwig; Elofsson, Mikael
Journal of Medicinal Chemistry, 2013 , vol. 56, # 23 p. 9556 - 9568
反应条件
triethyl phosphite in toluene 3 h; Heating;
参考文献
Witt, Anette; Gustavsson, Annika; Bergman, Jan
Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 1 p. 29 - 35
反应条件
in toluene 4 h; Heating;
参考文献
Usifoh
Scientia Pharmaceutica, 2000 , vol. 68, # 3 p. 275 - 279
反应条件
1.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C 1.2: 51 percent / tetrahydrofuran / 20 °C 2.1: 77 percent / triethyl phosphite / toluene / 3 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 1 p. 29 - 35
反应条件
1.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C 1.2: 51 percent / tetrahydrofuran / 20 °C 2.1: 77 percent / triethyl phosphite / toluene / 3 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 40, # 1 p. 29 - 35
反应条件
1: toluene / 4 h / 90 °C / |Inert atmosphere 2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water / 22 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 23 p. 9556 - 9568
反应条件
1: toluene / 4 h / 90 °C / |Inert atmosphere 2: potassium carbonate; urea hydrogen peroxide addition compound / acetone; water / 22 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 23 p. 9556 - 9568
