2-(4-异丁基苯基)-2-甲基丙酸合成路线 （共 4 条）
反应条件
potassium hydroxide in ethylene glycol
4 h; RefluxInert atmosphere;
参考文献
Yang, Mingyu; Jiang, Xingyu; Shi, Wen-Juan; Zhu, Qi-Lei; Shi, Zhang-Jie
Organic Letters, 2013 , vol. 15, # 3 p. 690 - 693
反应条件
1.1: thionyl chloride / 6 h / 0 - 20 °C
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 0 °C
2.2: 1 h / 0 °C
3.1: N-benzyl-trimethylammonium hydroxide / methanol; water / 3.5 h / 75 °C
View Scheme
参考文献
Banoglu, Erden; Caliskan, Burcu; Luderer, Susann; Eren, Goekcen; Oezkan, Yagmur; Altenhofen, Wolfram; Weinigel, Christina; Barz, Dagmar; Gerstmeier, Jana; Pergola, Carlo; Werz, Oliver
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3728 - 3741
反应条件
1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / -78 - 0 °C
1.2: 1 h / 0 °C
2.1: N-benzyl-trimethylammonium hydroxide / methanol; water / 3.5 h / 75 °C
View Scheme
参考文献
Banoglu, Erden; Caliskan, Burcu; Luderer, Susann; Eren, Goekcen; Oezkan, Yagmur; Altenhofen, Wolfram; Weinigel, Christina; Barz, Dagmar; Gerstmeier, Jana; Pergola, Carlo; Werz, Oliver
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 12 p. 3728 - 3741
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 30 min, 2.) THF, a) -78 deg C 30 min, b) RT; Yield given. Multistep reaction;
参考文献
Summers, James B.; Gunn, Bruce P.; Mazdiyasni, Hormoz; Goetze, Andrew M.; Young, Patrick R.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2121 - 2126
