(R)-(+)-4-异丙基-2-恶唑啉酮合成路线 (共 15 条)
反应条件
1: With N(Et)4(1+)*(2-pyrrolidone-anion) in acetonitrile T=20°C; Carboxylation; 1 h; 2: With p-toluenesulfonyl chloride in acetonitrile T=20°C; Cyclization; Further stages.;
参考文献
Casadei, M. Antonietta; Feroci, Marta; Inesi, Achille; Rossi, Leucio; Sotgiu, Giovanni
Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4759 - 4761
反应条件
sodium acetate; palladium diacetate in acetonitrile T=20°C; P=760 Torr; Electrolysis;
参考文献
Chiarotto, Isabella; Feroci, Marta
Tetrahedron Letters, 2001 , vol. 42, # 20 p. 3451 - 3453
反应条件
thionyl chloride in tetrahydrofuran T=0°C; 3 h;
参考文献
Matsunaga, Hirofumi; Ishizuka, Tadao; Kunieda, Takehisa
Tetrahedron, 1997 , vol. 53, # 4 p. 1275 - 1294
反应条件
1: H2 / Pd/C / methanol 2: Zn; acetone; CH3COOH View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 10 p. 1790 - 1793
反应条件
potassium carbonate in hexane; nitrogen; toluene
反应条件
potassium carbonate T=130°C; 3 h;
参考文献
Benoit, David; Coulbeck, Elliot; Eames, Jason; Motevalli, Majid
Tetrahedron Asymmetry, 2008 , vol. 19, # 9 p. 1068 - 1077
反应条件
n-butyllithium in tetrahydrofuran T=-78°C; 2 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 9 p. 1068 - 1077
反应条件
in toluene 18 h; Heating;
参考文献
Kleschick, William A.; Reed, Michael W.; Bordner, Jon
Journal of Organic Chemistry, 1987 , vol. 52, # 14 p. 3168 - 3169
反应条件
1: Et3N, DMAP / CH2Cl2 / 9 h / Ambient temperature 2: 74 percent / NaBH4, MeOH / ethanol / 24 h / Ambient temperature 3: 100 percent / SOCl2 / tetrahydrofuran / 3 h / 0 °C View Scheme
参考文献
Tetrahedron, , vol. 53, # 4 p. 1275 - 1294
反应条件
sodium tetrahydroborate
参考文献
Synlett, , # 12 p. 1903 - 1905