2-氯-4-吗啉噻吩并[2,3-d]嘧啶-6-甲醛合成路线

参考文献

GENENTECH, INC.; PIRAMED LIMITED
Patent: WO2007/127183 A1, 2007 ;
Location in patent: Page/Page column 137 ;
WO 2007/127183 A1

68-12-2N,N-二甲基甲酰胺+

63894-67-72-氯-4-吗啡啉基噻吩并[2,3-D]嘧啶

955978-98-02-氯-4-吗啉噻吩并[2,3-d]嘧啶-6-甲醛

参考文献

Heffron, Timothy P.; Wei, Binqing; Olivero, Alan; Staben, Steven T.; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J.; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P.; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing-Yan
Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7815 - 7833

18740-39-12,4-二氯噻吩并[2,3-d]嘧啶

955978-98-02-氯-4-吗啉噻吩并[2,3-d]嘧啶-6-甲醛

参考文献

Heffron, Timothy P.; Wei, Binqing; Olivero, Alan; Staben, Steven T.; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J.; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P.; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing-Yan
Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7815 - 7833

4651-81-42-氨基噻吩-3-羧酸甲酯

955978-98-02-氯-4-吗啉噻吩并[2,3-d]嘧啶-6-甲醛

参考文献

Heffron, Timothy P.; Wei, Binqing; Olivero, Alan; Staben, Steven T.; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J.; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P.; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing-Yan
Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7815 - 7833

18740-38-02,4-二羟基噻吩[2,3-D]嘧啶

955978-98-02-氯-4-吗啉噻吩并[2,3-d]嘧啶-6-甲醛

参考文献

Heffron, Timothy P.; Wei, Binqing; Olivero, Alan; Staben, Steven T.; Tsui, Vickie; Do, Steven; Dotson, Jennafer; Folkes, Adrian J.; Goldsmith, Paul; Goldsmith, Richard; Gunzner, Janet; Lesnick, John; Lewis, Cristina; Mathieu, Simon; Nonomiya, Jim; Shuttleworth, Stephen; Sutherlin, Daniel P.; Wan, Nan Chi; Wang, Shumei; Wiesmann, Christian; Zhu, Bing-Yan
Journal of Medicinal Chemistry, 2011 , vol. 54, # 22 p. 7815 - 7833