2-氨基-N-(2-氯吡啶-3-基)苯甲酰胺合成路线 （共 16 条）
反应条件
PPA; water; ammonium chloride
1) 160 deg C, 4 h, 2) r.t.; Yield given. Multistep reaction;
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t.
2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
3: acetonitrile / 2 h / 80 °C
4: 95 percent / toluene / 2 h / 80 °C
5: 0.28 g / 50percent aq. KOH / tetrabutylammonium chloride / toluene / 2 h / Heating
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t.
2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
3: acetonitrile / 2 h / 80 °C
4: 100 percent / toluene / 2 h / 80 °C
5: H2 / Raney nickel / ethanol / 8 h / 60 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t.
2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
3: acetonitrile / 2 h / 80 °C
4: 100 percent / toluene / 2 h / 80 °C
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 1) NH4Cl, polyphosphoric acid, 2) H2O / 1) 160 deg C, 4 h, 2) r.t.
2: 95 percent / 40percent H2O2, acetic acid / 50 deg C, 3 h, then 20-25 deg C, 24 h
3: 65 percent / 50percent aq. KOH / tetrabutylammonium chloride / toluene / 4 h / Heating
View Scheme
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: 97 percent / pyridine / tetrahydrofuran / 0.25 h / 0 °C
2: 100 percent / Et3N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C
3: 82 percent / NaOMe / tetrahydrofuran / 20 °C
View Scheme
参考文献
Fuwa, Haruhiko; Kobayashi, Toshitake; Tokitoh, Takashi; Torii, Yukiko; Natsugari, Hideaki
Synlett, 2004 , # 14 p. 2497 - 2500
