1-苄基-4-羟基哌啶-3-羧酸甲酯合成路线 (共 3 条)
反应条件
1: With triethylamine in methanol
T=20°C; 0.166667 h;
2: With sodium tetrahydroborate in methanol
T=20°C; 3 h;
3: With hydrogenchloride; methanol; water; sodium hydrogencarbonate
more than 3 stages;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122258 A1, 2007 ;
Location in patent: Page/Page column 59 ;
反应条件
sodium tetrahydroborate; sodium carbonate in isopropyl alcohol
T=20°C; 3 h;
参考文献
Furegati, Stefan; Ganci, Walter; Gorla, Fabrizio; Ringeisen, Urs; Rueedi, Peter
Helvetica Chimica Acta, 2004 , vol. 87, # 10 p. 2629 - 2661
反应条件
lithium aluminium tetrahydride in diethyl ether
T=20°C; 2 h;
参考文献
Furegati, Stefan; Ganci, Walter; Gorla, Fabrizio; Ringeisen, Urs; Rueedi, Peter
Helvetica Chimica Acta, 2004 , vol. 87, # 10 p. 2629 - 2661