4-氨基-1-叔-丁基-3-(3-溴苄基)吡唑并[3,4-d]嘧啶合成路线 （共 4 条）
反应条件
1: oxalyl dichloride / N,N-dimethyl-formamide; hexane / 1 h / 20 °C
2: sodium hydride / tetrahydrofuran / 1 h / 20 °C
3: sodium hydrogencarbonate / water; 1,4-dioxane / 1 h / |Reflux
4: ethanol / 1 h / |Reflux
5: 8 h / 160 - 180 °C
View Scheme
参考文献
Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; Wang, Qiuling; Wildman, Scott A.; Shokat, Kevan M.; Sibley, L. David
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3068 - 3077
反应条件
1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
2: sodium hydrogencarbonate / water; 1,4-dioxane / 1 h / |Reflux
3: ethanol / 1 h / |Reflux
4: 8 h / 160 - 180 °C
View Scheme
参考文献
Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; Wang, Qiuling; Wildman, Scott A.; Shokat, Kevan M.; Sibley, L. David
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3068 - 3077
参考文献
Chapman, Eli; Farr, George W.; Furtak, Krystyna; Horwich, Arthur L.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 811 - 813
反应条件
1: ethanol / 1 h / |Reflux
2: 8 h / 160 - 180 °C
View Scheme
参考文献
Lourido, Sebastian; Zhang, Chao; Lopez, Michael S.; Tang, Keliang; Barks, Jennifer; Wang, Qiuling; Wildman, Scott A.; Shokat, Kevan M.; Sibley, L. David
Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 3068 - 3077
