7,10-二(2,2,2-三氯乙氧羰基)-10-脱乙酰基巴卡丁 III合成路线 （共 8 条）
反应条件
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 78 percent / HCOOH / 4 h / 20 °C 3: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C View Scheme
参考文献
SAMYANG GENEX CORPORATION
Patent: US2012/35379 A1, 2012 ;
反应条件
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 78 percent / HCOOH / 4 h / 20 °C 3: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C 4: 90 percent / Zn, HOAc / methanol / 1 h / 60 °C View Scheme
参考文献
SAMYANG GENEX CORPORATION
Patent: US2012/35379 A1, 2012 ;
反应条件
4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide 1.) toluene; Multistep reaction;
参考文献
Denis; Kanazawa; Greene
Tetrahedron Letters, 1994 , vol. 35, # 1 p. 105 - 108
反应条件
1: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 2: 78 percent / HCOOH / 4 h / 20 °C View Scheme
参考文献
Chang, Jun; Hao, Xiao-Dong; Hao, Yun-Peng; Lu, Hong-Fu; Yu, Jian-Ming; Sun, Xun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6834 - 6837
反应条件
pyridine
T=0 - 20°C;
参考文献
Afon'Kin; Kostrikin; Shumeiko; Popov; Matveev; Matvienko; Zabudkin
Russian Chemical Bulletin, 2012 , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., 2012 , # 11 p. 2132 - 2145,14
反应条件
pyridine in dichloromethane
T=25 - 30°C; Inert atmosphere;
参考文献
Sekhar; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli
Synthetic Communications, 2012 , vol. 42, # 23 p. 3482 - 3492
反应条件
pyridine in dichloromethane
T=25 - 30°C; Inert atmosphere;
参考文献
Sekhar; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli
Synthetic Communications, 2012 , vol. 42, # 23 p. 3482 - 3492
反应条件
caesium carbonate
0.5 h; Cooling;
参考文献
Afon'Kin; Kostrikin; Shumeiko; Popov; Matveev; Matvienko; Zabudkin
Russian Chemical Bulletin, 2012 , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., 2012 , # 11 p. 2132 - 2145,14
