NaBO3 in tetrahydrofuran; water T=20°C;

2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene Desulfurization;

1: iodoacetic acid ethyl ester With C24H26N2O2 in diethyl ether T=25°C; Reformatsky reaction; 0.0833333 h; Inert atmosphere; 2: With boric acid trimethyl ester in diethyl ether Reformatsky reaction; 0.0833333 h; 3: isobutyraldehyde With dimethyl zinc in diethyl ether; toluene Reformatsky reaction; enantioselective reaction;

in ethanol T=0°C; transesterification; 20 h; Title compound not separated from byproducts.;

samarium diiodide; sodium ethanolate 1.) THF, -78 deg C, 0.5 h; Multistep reaction. Title compound not separated from byproducts;

Yield given. Multistep reaction. Title compound not separated from byproducts;