乙基3-外双环氨基[2.2.1]庚烷-2-外羧酸盐酸盐合成路线 (共 6 条)
反应条件
thionyl chloride T=-10°C; Reflux;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
Location in patent: Page/Page column 95-96 ;
反应条件
thionyl chloride 0 deg C, 0.5 h; RT, 3 h; reflux, 1 h;
参考文献
Stajer, Geza; Szabo, Angela E.; Fueloep, Ferenc; Bernath, Gabor; Sohar, Pal
Chemische Berichte, 1987 , vol. 120, p. 259 - 264
反应条件
1.1: ethyl acetate / 0 - 25 °C / Industry scale 1.2: 0 - 25 °C / Industry scale 1.3: 0 - 15 °C / pH 7 / Industry scale 2.1: hydrogenchloride / water / 12 h / 25 °C 3.1: thionyl chloride / 0 °C / Reflux View Scheme
反应条件
1: hydrogenchloride / water / 12 h / 25 °C 2: thionyl chloride / 0 °C / Reflux View Scheme
反应条件
sodium hydrogencarbonate T=25°C; 0.5 h;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
Location in patent: Page/Page column 96 ;
参考文献
Anadys Pharmaceuticals, Inc.
Patent: US2012/316156 A1, 2012 ;