反-8-甲基-6-壬酰氯合成路线 （共 17 条）
反应条件
thionyl chloride 1.) RT, 18 h, 2.) 100 deg C, 30 min;
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071
反应条件
1: 92 percent / aq. NaOH / methanol / 15 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 25 p. 8451 - 8470
反应条件
1: t-BuOK / dimethylformamide / 15 h / Ambient temperature 2: thionyl chloride / 1.) room temp., 8 h, 2.) 100 deg C, 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, p. 3477 - 3478
反应条件
1: conc. H2SO4 / Heating 2: pyridinium chlorochromate (PCC), sodium acetate / CH2Cl2 / 1.5 h / Ambient temperature 4: Na(Hg), MeOH / tetrahydrofuran / 8 h / -20 °C 5: aq. KOH / ethanol / 1 h / Heating 6: thionyl chloride / 1.) RT, 18 h, 2.) 100 deg C, 30 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071
反应条件
2: Na(Hg), MeOH / tetrahydrofuran / 8 h / -20 °C 3: aq. KOH / ethanol / 1 h / Heating 4: thionyl chloride / 1.) RT, 18 h, 2.) 100 deg C, 30 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071
反应条件
1: pyridinium chlorochromate (PCC), sodium acetate / CH2Cl2 / 1.5 h / Ambient temperature 3: Na(Hg), MeOH / tetrahydrofuran / 8 h / -20 °C 4: aq. KOH / ethanol / 1 h / Heating 5: thionyl chloride / 1.) RT, 18 h, 2.) 100 deg C, 30 min View Scheme
参考文献
Journal of Organic Chemistry, , vol. 53, # 5 p. 1064 - 1071
反应条件
1: Et3N / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 1 h 2: 1.) NaH, 2.) KI / 1.) DMF, THF, RT, 15 min, 2.) DMF, THF, 80 deg C, 3.5 h 3: 86 percent / DMSO, NaCl / H2O / 3 h / 170 °C 4: 92 percent / aq. NaOH / methanol / 15 h / Heating 5: SOCl2 / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 25 p. 8451 - 8470
反应条件
1: 1.) NaH, 2.) KI / 1.) DMF, THF, RT, 15 min, 2.) DMF, THF, 80 deg C, 3.5 h 2: 86 percent / DMSO, NaCl / H2O / 3 h / 170 °C 3: 92 percent / aq. NaOH / methanol / 15 h / Heating 4: SOCl2 / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 25 p. 8451 - 8470
反应条件
1: 86 percent / LiAlH4 / diethyl ether / 15 h / Ambient temperature 2: Et3N / CH2Cl2 / 1.) 0 deg C, 30 min, 2.) RT, 1 h 3: 1.) NaH, 2.) KI / 1.) DMF, THF, RT, 15 min, 2.) DMF, THF, 80 deg C, 3.5 h 4: 86 percent / DMSO, NaCl / H2O / 3 h / 170 °C 5: 92 percent / aq. NaOH / methanol / 15 h / Heating 6: SOCl2 / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 25 p. 8451 - 8470
反应条件
1: 86 percent / DMSO, NaCl / H2O / 3 h / 170 °C 2: 92 percent / aq. NaOH / methanol / 15 h / Heating 3: SOCl2 / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 25 p. 8451 - 8470
