1: With n-butyllithium in tetrahydrofuran; pentane T=-78 - 18°C; 1.5 h; Inert atmosphere; 2: With water in tetrahydrofuran; pentane T=-20 - 18°C; 1 h; Inert atmosphere;

1.1: p-methylbenzenesulfonyl (tosylate) / dichloromethane / 24.5 h / 5 - 18 °C / |Inert atmosphere 2.1: trifluoroacetic acid / dichloromethane / 24 h / |Reflux 3.1: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 24 h / 18 °C / |Inert atmosphere; |Darkness 4.1: n-butyllithium / tetrahydrofuran; pentane / 1.5 h / -78 - 18 °C / |Inert atmosphere 4.2: 1 h / -20 - 18 °C / |Inert atmosphere View Scheme

1.1: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 24 h / 18 °C / |Inert atmosphere; |Darkness 2.1: n-butyllithium / tetrahydrofuran; pentane / 1.5 h / -78 - 18 °C / |Inert atmosphere 2.2: 1 h / -20 - 18 °C / |Inert atmosphere View Scheme