2-氯-6-甲氧基烟酸甲酯合成路线 （共 18 条）
反应条件
1: T=20°C; 1 h; Industry scale; 2: With sodium hydrogencarbonate
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
Patent: US2012/172391 A1, 2012 ;
Location in patent: Page/Page column 77; 78 ;
US 20120172391 A1
反应条件
1: 2-Chloro-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid With lithium hydride in N,N-dimethyl-formamide 0.666667 h; 2: methyl iodide in N,N-dimethyl-formamide 0.75 h; Product distribution / selectivity;
参考文献
ARRAY BIOPHARMA INC.; ASTRAZENECA AB
Patent: WO2007/44084 A2, 2007 ;
Location in patent: Page/Page column 76; 77 ;
WO 2007/044084 A2
反应条件
hydrogenchloride in methanol 0.25 h; Heating;
参考文献
Dainter, Ronald S.; Suschitzky, Hans; Wakefield, Basil J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 227 - 234
反应条件
in methanol; diethyl ether; dichloromethane T=0 - 20°C; 0.666667 h;
参考文献
Just-Baringo, Xavier; Albericio, Fernando; Alvarez, Mercedes
European Journal of Organic Chemistry, 2013 , # 28 p. 6404 - 6419
反应条件
1: 84 percent / t-BuOK / 96 h / Heating 2: SOCl2 / 5 h / Heating 3: 4.0 g / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 5 p. 702 - 715
反应条件
1: 1.) Na / 2.) reflux, 10 min 2: 86 percent / 2 M HCl / methanol / 0.25 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 227 - 234
反应条件
1: SOCl2 / 5 h / Heating 2: 4.0 g / 1 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 5 p. 702 - 715
反应条件
1: 1.) 5 eq.Na / 2.) room t., 6 h 2: 86 percent / 2 M HCl / methanol / 0.25 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 227 - 234
反应条件
1: 1.) 1 aq. Na / 2.) 48 h, room t., 2: 1.) 5 eq.Na / 2.) room t., 6 h 3: 86 percent / 2 M HCl / methanol / 0.25 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 227 - 234
反应条件
in tetrahydrofuran T=20°C; 4 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 12 p. 1847 - 1853
