2-氯-6-甲氧基烟酸甲酯合成路线 （共 18 条）
反应条件
in dichloromethane T=20°C; 4 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 48, # 12 p. 1847 - 1853
参考文献
Tetrahedron Letters, , vol. 25, # 49 p. 5693 - 5696
反应条件
1: thionyl chloride / 5 h / 80 °C / Industry scale 2: 1 h / 20 °C / Industry scale View Scheme
参考文献
US2012/172391 A1, ;
US 20120172391 A1
反应条件
sodium hydroxide in methanol 0.5 h; Heating;
参考文献
Dainter, Ronald S.; Suschitzky, Hans; Wakefield, Basil J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 227 - 234
反应条件
1: 84 percent / H2 / 5 percent Pd/C / methanol / Ambient temperature; in presence of KOAc 2: 2 M NaOH / methanol / 0.5 h / Heating View Scheme
参考文献
Dainter, Ronald S.; Suschitzky, Hans; Wakefield, Basil J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 227 - 234
反应条件
hydrogen; palladium on activated charcoal in methanol Ambient temperaturein presence of KOAc;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 227 - 234
反应条件
1: 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere 2: ammonia / methanol / 24 h / 100 °C / Sealed vessel View Scheme
参考文献
Conn, P. Jeffrey; Lindsley, Craig W.; Stauffer, Shaun R.; Manka, Jason; Jacobs, Jon; Zhou, Ya; Bartolomé-Nebreda, José Manuel; Macdonald, Gregor James; Conde-Ceide, Susana; Jones, Carrie K.
Patent: US2012/172391 A1, 2012 ;
US 20120172391 A1
反应条件
in ethanol; water
12 h; Heating;
参考文献
Hirokawa, Yoshimi; Fujiwara, Iwao; Suzuki, Kenji; Harada, Hiroshi; Yoshikawa, Takashi; Yoshida, Naoyuki; Kato, Shiro
Journal of Medicinal Chemistry, 2003 , vol. 46, # 5 p. 702 - 715
