4-羟基-2,6-二甲基苯甲腈合成路线 (共 12 条)
反应条件
1: hydrogenchloride / water; methanol / 7 h / 20 °C 2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 40 h / 80 °C / Inert atmosphere 3: sodium hydrogencarbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol; water / 1 h / 120 °C / Inert atmosphere; Microwave irradiation View Scheme
参考文献
WO2011/130628 A1, ;
WO 2011/130628 A1
反应条件
1.1: dichloromethane / 3 h / 20 °C 2.1: titanium(IV) isopropylate; triethylamine / chloroform / |Reflux 2.2: 12 h / 20 °C 3.1: sodium hydrogencarbonate; bis-triphenylphosphine-palladium(II) chloride / water; toluene / 1 h / 120 °C / |Inert atmosphere; |Microwave irradiation View Scheme