1: 4-fluoro-1-iodobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.0833333 h; 2: With di-tert-butylazodicarboxylate in tetrahydrofuran; hexane T=-78 - 23°C; 0.5 h; 3: 2-bromo-1,3-propanedial With sulfuric acid in tetrahydrofuran; 1,4-dioxane; hexane T=80°C; 0.166667 h;

bromine; acetic acid T=20°C; regioselective reaction;

tris-(dibenzylideneacetone)dipalladium(0); AdBrettPhos; ammonia; sodium t-butanolate in 1,4-dioxane T=120°C; 20 h; Inert atmosphere; Reagent/catalyst;