(R)-(+)-3-叔丁氧羰基-2,2-二甲基-4-噁唑烷羧酸甲合成路线 （共 16 条）
反应条件
toluene-4-sulfonic acid in benzene 3 h; Ambient temperature;
参考文献
Uchida, Hideharu; Nishida, Atsushi; Nakagawa, Masako
Tetrahedron Letters, 1999 , vol. 40, # 1 p. 113 - 116
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 12 h / 20 °C 2: BF3*Et2O / acetone / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 11 p. 3064 - 3067
反应条件
1: 95 percent / K2CO3 / dimethylformamide / 20 h / 20 °C 2: 92 percent / p-toluenesulfonic acid / toluene / 20 h / Heating View Scheme
参考文献
Organic Letters, , vol. 5, # 23 p. 4253 - 4256
反应条件
in methanol; hexane; benzene T=20°C; 1 h; Inert atmosphere;
参考文献
Lin, Chun-Chieh; Tantisantisom, Worawan; McAlpine, Shelli R.
Organic Letters, 2013 , vol. 15, # 14 p. 3574 - 3577
参考文献
Chun, Jiong; Byun, Hoe-Sup; Arthur, Gilbert; Bittman, Robert
Journal of Organic Chemistry, 2003 , vol. 68, # 2 p. 355 - 359
反应条件
1: 95 percent / Et3N / dioxane; H2O 2: 93 percent 3: 70 percent / H(1+) View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 25 p. 3037 - 3040
反应条件
1: NaOH 3: 60 percent / p-toluenesulphonic acid View Scheme
参考文献
Tetrahedron Letters, , vol. 25, # 51 p. 5855 - 5858
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 1 p. 10 - 12
反应条件
1: ethyl acetate With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; Metallation; 1 h; 2: Garner's ester in tetrahydrofuran; hexane T=-78°C; Claisen condensation; 12 h;
参考文献
Boesche, Uwe; Nubbemeyer, Udo
Tetrahedron, 1999 , vol. 55, # 22 p. 6883 - 6904
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h; 2: With sodium hydroxide in tetrahydrofuran; water
参考文献
CHUGAI SEIYAKU KABUSHIKI KAISHA
Patent: WO2005/87700 A2, 2005 ;
Location in patent: Page/Page column 322 ;
WO 2005/087700 A2
