(R)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛合成路线 （共 41 条）
反应条件
diisobutylaluminium hydride in toluene T=-60 - 0°C; 2.5 h;
参考文献
Hu, X. Eric; Kim, Nick K.; Ledoussal, Benoit
Organic Letters, 2002 , vol. 4, # 25 p. 4499 - 4502
反应条件
Dess-Martin periodane in dichloromethane 2 h; Ambient temperature;
参考文献
Avenoza; Cativiela; Corzana; Peregrina; Zurbano
Synthesis, 1997 , # 10 p. 1146 - 1150
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.5 h;
参考文献
Campbell, Andrew D.; Raynham, Tony M.; Taylor, Richard J. K.
Synthesis, 1998 , # 12 p. 1707 - 1709
反应条件
bis[(R,R,S)-DiazaPhos-SPE] in tetrahydrofuran T=55°C; P=7240.26 Torr; 72 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Clemens, Alexander J. L.; Burke, Steven D.
Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2983 - 2985
反应条件
1: 80 percent / p-TsOH / benzene / 1 h / Heating 2: 75 percent / DIBAL-H / toluene / 2 h / -78 °C View Scheme
参考文献
Chemistry and Physics of Lipids, , vol. 142, # 1-2 p. 58 - 69
反应条件
1: NaOH / dioxane; H2O / 48 h / 0 - 20 °C 2: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride, N-methylmorpholine / CH2Cl2 / 1 h / -15 °C 3: BF3*Et2O / acetone / 1.5 h / Ambient temperature 4: 100 percent / LiAlH4 / tetrahydrofuran / 0.5 h / 0 °C View Scheme
参考文献
Synthesis, , # 12 p. 1707 - 1709
反应条件
1: 86 percent / K2CO3 / dimethylformamide / 1.5 h / 0 - 20 °C 2: 80 percent / p-TsOH / benzene / 1 h / Heating 3: 75 percent / DIBAL-H / toluene / 2 h / -78 °C View Scheme
参考文献
Chemistry and Physics of Lipids, , vol. 142, # 1-2 p. 58 - 69
反应条件
1: imidazole / CH2Cl2 / 12 h / Ambient temperature 2: LiBH4 / tetrahydrofuran / 12 h / Ambient temperature 3: 94 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 4: 98 percent / Bu4NF / tetrahydrofuran / 2 h / Ambient temperature 5: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 1146 - 1150
反应条件
1: 98 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 2: 95 percent / H2 / Pd/C / ethyl acetate / 24 h / Ambient temperature 3: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 1146 - 1150
反应条件
1: 98 percent / LiBH4 / tetrahydrofuran / 12 h / Ambient temperature 2: 98 percent / BF3*Et2O / acetone / 2 h / Ambient temperature 3: 95 percent / H2 / Pd/C / ethyl acetate / 24 h / Ambient temperature 4: 93 percent / Dess-Martin periodinane / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 10 p. 1146 - 1150
