(R)-(+)-3-Boc-2,2-二甲基噁唑啉-4-甲醛合成路线 （共 41 条）
反应条件
RuCl(Ph3P)3; triphenylphosphine in tetrahydrofuran; isopropyl alcohol T=25°C; 4 h; Title compound not separated from byproducts;
参考文献
Lebel, Heandleandne; Paquet, Valeandrie; Proulx, Caroline
Angewandte Chemie - International Edition, 2001 , vol. 40, # 15 p. 2887 - 2890
反应条件
trimethylaluminum; zinc in tetrahydrofuran 12 h; Ambient temperature;
参考文献
Moriwake, Toshio; Hamano, Shin-ichi; Saito, Seiki; Torii, Sigeru
Chemistry Letters, 1987 , p. 2085 - 2088
反应条件
in tetrahydrofuran; hexane T=25°C; 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Beaulieu, Pierre L.; Duceppe, Jean-Simon; Johnson, Carolyne
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4196 - 4204
反应条件
potassium carbonate in methanol T=0 - 20°C; 3 h; Inert atmosphere;
参考文献
Usuki, Toyonobu; Yamada, Haruka; Hayashi, Takahiro; Yanuma, Hiroto; Koseki, Yohei; Suzuki, Noriyuki; Masuyama, Yoshiro; Lin, Yong Y.
Chemical Communications, 2012 , vol. 48, # 26 p. 3233 - 3235
反应条件
1: (2-oxo-propyl)-phosphonic acid dimethyl ester With 4-Acetylaminobenzenesulfonyl Azide; potassium carbonate in chloroform T=0 - 10°C; 48 h; Inert atmosphere; 2: 1,1-Dimethylethyl (R)-4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate in methanol; chloroform T=0°C; Bestmann-Ohira reaction; 24 h; Inert atmosphere;
参考文献
Spangenberg, Thomas; Schoenfelder, Angele; Breit, Bernhard; Mann, Andre
European Journal of Organic Chemistry, 2010 , # 31 p. 6005 - 6018
反应条件
1: 1.) PPh3, 2.) Et3N / 1) CH2Cl2, -20 deg C, 30 min; 2) CH2Cl2, -60 deg C, 30 min, rt, overnight 2: 58 percent / BuLi / tetrahydrofuran / 1) -78 deg C, 30 min; 2) -15 deg C, 15 min View Scheme
参考文献
Yamakawa, Takayuki; Ideue, Eiji; Iwaki, Yuzo; Sato, Ayumu; Tokuyama, Hidetoshi; Shimokawa, Jun; Fukuyama, Tohru
Tetrahedron, 2011 , vol. 67, # 35 p. 6547 - 6560
反应条件
1: 1.) PPh3, 2.) Et3N / 1) CH2Cl2, -20 deg C, 30 min; 2) CH2Cl2, -60 deg C, 30 min, rt, overnight 2: BuLi / tetrahydrofuran / 1) -78 deg C, 30 min; 2) -15 deg C, 15 min View Scheme
参考文献
Reginato, Gianna; Mordini, Alessandro; Caracciolo, Massimo
Journal of Organic Chemistry, 1997 , vol. 62, # 18 p. 6187 - 6192
反应条件
1: 84 percent / BF3*OEt2 / CH2Cl2 / 8 h / -80 °C 2: 65 percent / Et3N, 4-(N,N-dimethylamino)pyridine / CH2Cl2 / 4 h / Ambient temperature 3: pyridine / 3 h / Ambient temperature 4: dicyclohexane-crown-6, KMnO4 / CH2Cl2 / 1) 15 deg C, 3 h, 2) room temp., 3 h 5: pyridine / 5 h / Ambient temperature View Scheme
参考文献
Casiraghi, Giovanni; Colombo, Lino; Rassu, Gloria; Spanu, Pietro
Journal of Organic Chemistry, 1991 , vol. 56, # 23 p. 6523 - 6527
反应条件
RuCl(Ph3P)3; triphenylphosphine in tetrahydrofuran; isopropyl alcohol
T=25°C; 4 h; Title compound not separated from byproducts;
参考文献
Lebel, Heandleandne; Paquet, Valeandrie; Proulx, Caroline
Angewandte Chemie - International Edition, 2001 , vol. 40, # 15 p. 2887 - 2890
反应条件
in tetrahydrofuran; hexane
T=25°C; 4 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Beaulieu, Pierre L.; Duceppe, Jean-Simon; Johnson, Carolyne
Journal of Organic Chemistry, 1991 , vol. 56, # 13 p. 4196 - 4204
