3,6-二溴吡嗪-2-甲酸合成路线 （共 5 条）
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=0°C; 0.75 h; 2: With hydrogenchloride in dichloromethane; water
参考文献
de Vicente Fidalgo, Javier; Hermann, Johannes Cornelius; Lemoine, Remy; Li, Hongju; Lovey, Allen John; Sjogren, Eric Brian; Soth, Michael
Patent: US2011/59118 A1, 2011 ;
Location in patent: Page/Page column 57 ;
反应条件
1.1: bromine; hydrogen bromide; acetic acid / water / 0.75 h / 0 °C 1.2: 0.5 h / 0 °C 2.1: water; lithium hydroxide hydrate / tetrahydrofuran / 0.75 h / 0 °C View Scheme
反应条件
1.1: bromine; acetic acid / water / 1 h / 25 - 45 °C 2.1: bromine; hydrogen bromide; acetic acid / water / 0.75 h / 0 °C 2.2: 0.5 h / 0 °C 3.1: water; lithium hydroxide hydrate / tetrahydrofuran / 0.75 h / 0 °C View Scheme
反应条件
1: sulfuric acid 2: bromine; acetic acid 3: hydrogen bromide; sodium nitrite / water 4: water; lithium hydroxide hydrate / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 6 p. 2266 - 2270
反应条件
1: With diphenyl phosphoryl azide; triethylamine in tert-butyl alcohol 18 h; Reflux; 2: With trifluoroacetic acid in dichloromethane 0.5 h; 3: With sodium hydroxide in dichloromethane; water
参考文献
WIGERINCK, Piet Tom Bert Paul; ANDREWS, Martin James Inglis; De WEER, Marc Maurice Germain; SABOURAULT, Nicholas Luc; KLUGE, Stefan Christian
Patent: US2011/118269 A1, 2011 ;
Location in patent: Page/Page column 13 ;
