4-氨基-1-(2-脱氧-2-氟-beta-D-阿拉伯糖呋喃基)-5-乙基-2(1H)-嘧啶酮合成路线 （共 7 条）
反应条件
ammonia in methanol
T=90°C; 29 h;
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
hydrogen; palladium on activated charcoal in methanol
P=1034.3 Torr; 4.5 h;
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
2: H2 / 10percent Pd/C / methanol / 4.5 h / 1034.3 Torr
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
1: 86 percent / pyridine / Ambient temperature
2: P2S5 / dioxane / 3 h / Heating
3: NaOMe / methanol / 1.25 h / Heating
4: methanol; H2O / Ambient temperature
5: 78 percent / NH3 gas / methanol / 29 h / 90 °C
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
1: P2S5 / dioxane / 3 h / Heating
2: NaOMe / methanol / 1.25 h / Heating
3: methanol; H2O / Ambient temperature
4: 78 percent / NH3 gas / methanol / 29 h / 90 °C
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
1: methanol; H2O / Ambient temperature
2: 78 percent / NH3 gas / methanol / 29 h / 90 °C
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
反应条件
1: NaOMe / methanol / 1.25 h / Heating
2: methanol; H2O / Ambient temperature
3: 78 percent / NH3 gas / methanol / 29 h / 90 °C
View Scheme
参考文献
Perlman; Watanabe; Schinazi; Fox
Journal of Medicinal Chemistry, 1985 , vol. 28, # 6 p. 741 - 748
