3-羟基四氢-吡啶甲酸苄酯合成路线 （共 8 条）
反应条件
sodium carbonate in tetrahydrofuran; water T=20°C; 5 h;
参考文献
YM BIOSCIENCES AUSTRALIA PTY LTD; BURNS, Christopher John
Patent: WO2014/32 A1, 2014 ;
Location in patent: Page/Page column 44; 45 ;
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water; toluene Ambient temperature;
参考文献
Kikuchi, Haruhisa; Yamamoto, Keisuke; Horoiwa, Seiko; Hirai, Shingo; Kasahara, Ryota; Hariguchi, Norimitsu; Matsumoto, Makoto; Oshima, Yoshiteru
Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4698 - 4706
反应条件
triethylamine in dichloromethane
反应条件
sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane 1.) THF, 25 deg C, 1 h, 2.) 25 deg C, 6 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 50, # 10 p. 1582 - 1589
反应条件
1: triethylamine / dichloromethane / 0 °C 2: potassium carbonate / N,N-dimethyl-formamide / 10 - 80 °C View Scheme
参考文献
Zhersh, Sergey; Buryanov, Volodymyr V.; Karpenko, Oleksandr V.; Grygorenko, Oleksandr O.; Tolmachev, Andrey A.
Synthesis, 2011 , # 22 art. no. Z72611SS, p. 3669 - 3674
反应条件
1: 99 percent / toluene / 5.5 h / 100 °C 2: 50 percent / phosphate buffer / dioxane / 90 h / 25 °C / lipase PS View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
反应条件
chromium(VI) oxide; sulfuric acid in acetone 0.5 h; Ambient temperature;
参考文献
Apostolopoulos; Haroutounian
Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 6 p. 1843 - 1845
反应条件
1: 99 percent / toluene / 5.5 h / 100 °C
2: 50 percent / phosphate buffer / dioxane / 90 h / 25 °C / lipase PS
3: H2 / 5percent Pd/C
View Scheme
参考文献
Tomori, Hiroshi; Shibutani, Kuniko; Ogura, Katsuyuki
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 1 p. 207 - 215
