甲基2,5-二甲基-4-苯基-1H-吡咯-3-羧酸酯合成路线 （共 8 条）
反应条件
anhydrous iron chloride in ethylene glycol
T=100°C; 4 h;
参考文献
Li, Liang; Zhao, Mi-Na; Ren, Zhi-Hui; Li, Jianli; Guan, Zheng-Hui
Synthesis, 2012 , vol. 44, # 4 p. 532 - 540
反应条件
carbamic acid 1,1-dimethylethyl ester; [Ru(η3-2-C3H4Me)(CO)(1,1'-(Ph2P)2-ferrocene)][SbF6]; trifluoroacetic acid in tetrahydrofuran
T=20 - 75°C; Inert atmosphere;
参考文献
Cadierno, Victorio; Gimeno, Jose; Nebra, Noel
Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 1 p. 233 - 236
反应条件
hydrogenchloride in methanol; water
Heating;
参考文献
Boberg, Friedrich; Garburg, Karl-Heinz; Goerlich, Karl-Joachim; Pipereit, Eberhard; Ruhr, Maria
Liebigs Annalen der Chemie, 1985 , # 2 p. 239 - 250
反应条件
1: 65 percent / methanol / 8 h / 20 °C
2: 87 percent / sulphuric acid, methanol / 6 h / Heating
3: NH2OH / methanol
4: 1.) H2 / 1.) Raney-Ni / 1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux
View Scheme
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
反应条件
1: 87 percent / sulphuric acid, methanol / 6 h / Heating
2: NH2OH / methanol
3: 1.) H2 / 1.) Raney-Ni / 1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux
View Scheme
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
反应条件
1: 65 percent / methanol / 8 h / 20 °C
2: 87 percent / sulphuric acid, methanol / 6 h / Heating
3: NH2OH / methanol
4: 1.) H2 / 1.) Raney-Ni / 1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux
View Scheme
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
反应条件
1: NH2OH / methanol
2: 1.) H2 / 1.) Raney-Ni / 1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux
View Scheme
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
反应条件
hydrogen; nickel
1.) methanol, 2.5 kg/cm3, 3.5 h, 2.) methanol, p-TSA, 8h, reflux; Yield given. Multistep reaction;
参考文献
Akhtar, M. S.; Sharma, V. L.; Seth, M.; Bhaduri, A. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 448 - 451
