5-乙基-4-(2-苯氧基乙基)-2H-1,2,4-三氮唑-3(4H)-酮合成路线 (共 7 条)
反应条件
potassium hydroxide in water T=95 - 96°C; 0.666667 h;
参考文献
Madding; Smith; Sheldon; Lee
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1121 - 1126
反应条件
1: toluene / 0.25 h / ice bath 2: 64 percent / KOH / H2O / 0.67 h / 95 - 96 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 4 p. 1121 - 1126
反应条件
1: phosgene, imidazole / CH2Cl2 / 2.5 h / 25 °C 2: CH2Cl2 / 16 h / 25 °C 3: 1) 50percent aq. NaOH / 1) water-methylene chloride, 2) xylene, reflux, 2.5 h View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 4 p. 1121 - 1126
反应条件
1: 1) NaNO2, aq.HCl / 1) water, toluene, ice- bath, 20 min, 2) toluene, steam bath 2: toluene / 0.25 h / ice bath 3: 64 percent / KOH / H2O / 0.67 h / 95 - 96 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 4 p. 1121 - 1126
反应条件
sodium hydroxide 1) water-methylene chloride, 2) xylene, reflux, 2.5 h; Yield given. Multistep reaction;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 4 p. 1121 - 1126
反应条件
sodium hydroxide in isopropyl alcohol 7 h; Heating;
参考文献
Madding; Smith; Sheldon; Lee
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1121 - 1126
反应条件
hydrogenchloride; sodium hydroxide in dichloromethane; isopropyl alcohol
参考文献
Mead Johnson and Company
Patent: US4487773 A1, 1984 ;
US 4487773 A