N-(2-乙氧基乙基)-2-硝基-苯胺合成路线 （共 9 条）
反应条件
1: 77 percent / 10percent aq. NaOH, Zn / ethanol / Heating 2: 69 percent / 5 h / 150 °C 3: 82 percent / POCl3 / 0.5 h / Heating 4: 81 percent / 4 h / 120 °C View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: Zn; HCl 2: Heating View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
potassium carbonate in 2-methyl tetrahydrofuran; dimethyl sulfoxide
T=10 - 45°C; 23.5 h; Inert atmosphere;
参考文献
ZENTIVA, K.S; ZEZULA, Josef; HAJICEK, Josef
Patent: WO2014/26657 A2, 2014 ;
Location in patent: Page/Page column 13; 14 ;
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
sodium hydride in N,N-dimethyl-formamide
T=30 - 35°C; Alkylation;
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
反应条件
1: 95.2 percent / 3 h / 100 °C
2: 55.5 percent / NaH in oil / dimethylformamide / 30 - 35 °C
View Scheme
参考文献
Goeker, Hakan; Ayhan-Kilcigil, Guelguen; Tuncbilek, Meral; Kus, Canan; Ertan, Rahmiye; Kendi, Engin; Oezbey, Sueheyla; Fort, Merce; Garcia, Celia; Farre, Antonio J.
Heterocycles, 1999 , vol. 51, # 11 p. 2561 - 2573
反应条件
1: Zn; HCl
2: Heating
3: POCl3
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
1: 77 percent / 10percent aq. NaOH, Zn / ethanol / Heating
2: 69 percent / 5 h / 150 °C
3: 82 percent / POCl3 / 0.5 h / Heating
4: 96 percent / 4 h / 120 °C
View Scheme
参考文献
Iemura; Kawashima; Fukuda; Ito; Tsukamoto
Journal of Medicinal Chemistry, 1986 , vol. 29, # 7 p. 1178 - 1183
反应条件
5 palladium on charcoal; hydrogen in ethanol
T=5 - 10°C; P=2250.23 - 3000.3 Torr; 3 h;
参考文献
ZENTIVA, K.S; ZEZULA, Josef; HAJICEK, Josef
Patent: WO2014/26657 A2, 2014 ;
Location in patent: Page/Page column 14 ;
