1: With pyridine; sodium dithionite; sodium acetate in methanol; water T=35 - 40°C; 20 h; Inert atmospheresealed vesselyellow light; 2: With iodine in methanol; water 3: With ammonium hydroxide in methanol; water T=50°C; 1 h;

1: 1.) pyridine, Na2S2O4 2.) I2 / 1.) MeOH, H2O, 35-40 deg C, 20 h; 2.) MeOH, H2O, 22 deg C, 30 min 2: 67 percent / conc. NH4OH / H2O / 1 h / 50 °C View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: sodium tetrahydroborate / dimethyl sulfoxide / 2.5 h / 20 &deg;C<br />2: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 &deg;C<br />3: acetic acid / methanol / 1 h / 20 &deg;C<br />4: dmap / ethyl acetate / 10 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 &deg;C<br />2: acetic acid / methanol / 1 h / 20 &deg;C<br />3: dmap / ethyl acetate / 10 &deg;C<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a> <br />T=22&deg;C;&nbsp;5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 71 percent / glacial AcOH / methanol / 1 h / Ambient temperature<br />2: 100 percent / pyridine / 5 h / 22 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 71 percent / glacial AcOH / methanol / 1 h / Ambient temperature<br />2: 100 percent / pyridine / 5 h / 22 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: ammonium hydroxide / water / 14 h / 22 &deg;C / pH 9 - 10 / yellow light<br />2: methanol / 1 h / 20 &deg;C / yellow light<br />3: pyridine / methanol / 0 - 20 &deg;C / yellow light<br /> <br /> &nbsp;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: hydrochlorid acid / water / 0 &deg;C<br />1.2: 1 h<br />2.1: pyridine / -5 - 20 &deg;C<br />3.1: sodium tetrahydroborate / dimethyl sulfoxide / 2.5 h / 20 &deg;C<br />4.1: hydrochlorid acid; water / dimethyl sulfoxide / 5 h / 20 &deg;C<br />5.1: acetic acid / methanol / 1 h / 20 &deg;C<br />6.1: dmap / ethyl acetate / 10 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: acetic acid / methanol / 1 h / 20 &deg;C<br />2: dmap / ethyl acetate / 10 &deg;C<br /> <br /> &nbsp;