1: 4,6-dichloropyrimidine-2-(methylthio)pyrimidine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: chloroformic acid ethyl ester in tetrahydrofuran; hexane T=-78 - 0°C; 1 h; Inert atmosphere;

1: 4,6-dichloropyrimidine-2-(methylthio)pyrimidine With (2,2,6,6-tetramethylpiperidinyl)MgCl*LiCl in tetrahydrofuran T=25°C; Inert atmosphere; 2: [(Cyanocarbonyl)oxy]ethane in tetrahydrofuran T=25°C; Inert atmosphere; chemoselective reaction;

triethylamine T=10 - 35°C; 2 h;

1: aminosulfonic acid; sodium chlorite / water; tert-butyl alcohol; tetrahydrofuran / 0.17 h / -10 - 35 °C 2: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C 3: triethylamine / 2 h / 10 - 35 °C View Scheme

1: oxalyl dichloride / N,N-dimethyl-formamide / toluene / 1 h / 10 - 35 °C 2: triethylamine / 2 h / 10 - 35 °C View Scheme