3-(2-丙基)-1,3-哌啶二羧酸-1-(1,1-二甲基乙基)酯合成路线 （共 2 条）
反应条件
1: With lithium hexamethyldisilazane in tetrahydrofuran
T=-72 - 0°C; 0.7 h;
2: With chloro-trimethyl-silane in tetrahydrofuran
T=-67 - 2.5°C; 3 h;
参考文献
JAPAN TOBACCO INC.
Patent: US2011/136778 A1, 2011 ;
Location in patent: Page/Page column 30 ;
US 20110136778 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.7 h / -72 - 0 °C
2.2: 3 h / -67 - 2.5 °C
View Scheme
参考文献
JAPAN TOBACCO INC.
Patent: US2011/136778 A1, 2011 ;
US 20110136778 A1
