1-N-Boc-4-(3-羧基甲基-4-氧代-3,4-二氢喹唑啉-6-基)哌嗪合成路线 （共 4 条）
反应条件
1: neat (no solvent) / 2 h / 110 °C
2: aq. NaOH / dioxane / 16 h
3: 3.1 g / HOBT, NMM, EDC / dimethylformamide / 16 h
4: H2 / 10percent Pd/C / ethanol / 3 h
5: 16 h / Heating
6: aq. LiOH / methanol / Ambient temperature
View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: aq. NaOH / dioxane / 16 h
2: 3.1 g / HOBT, NMM, EDC / dimethylformamide / 16 h
3: H2 / 10percent Pd/C / ethanol / 3 h
4: 16 h / Heating
5: aq. LiOH / methanol / Ambient temperature
View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
1: 3.1 g / HOBT, NMM, EDC / dimethylformamide / 16 h
2: H2 / 10percent Pd/C / ethanol / 3 h
3: 16 h / Heating
4: aq. LiOH / methanol / Ambient temperature
View Scheme
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
反应条件
lithium hydroxide in methanol
Ambient temperature;
参考文献
Hutchinson, John H.; Cook, Jacquelynn J.; Brashear, Karen M.; Breslin, Michael J.; Glass, Joan D.; Gould, Robert J.; Halczenko, Wasyl; Holahan, Marie A.; Lynch, Robert J.; Sitko, Gary R.; Stranieri, Maria T.; Hartman, George D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 23 p. 4583 - 4591
