2-羟基嘧啶-5-羧酸乙酯合成路线 （共 13 条）
反应条件
1.1: trichlorophosphate / 2 h / 117 °C / Cooling with ice
2.1: sodium hydroxide; water / tetrahydrofuran / 1.5 h
2.2: 1 h / pH 1.5 - 4
3.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 3 h / 20 °C
4.1: ammonia / 1,4-dioxane / 0.75 h / 20 °C
View Scheme
参考文献
Leclerc, Jean-Philippe; Li, Chun Sing; Ramtohul, Yeeman K.
Patent: US2011/152295 A1, 2011 ;
反应条件
1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux
2: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / 20 °C
View Scheme
参考文献
CURIS, INC.
Patent: WO2009/36016 A1, 2009 ;
反应条件
1.1: trichlorophosphate; N,N-dimethyl-aniline / 1.5 h / Reflux
1.2: Cooling with ice
2.1: N,N-dimethyl-formamide / 1.5 h / 20 °C
View Scheme
参考文献
Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng
Patent: US2013/102595 A1, 2013 ;
