反应条件
1: 3,4-dichloropyridine With 2,2,6,6-tetramethyl-piperidine; n-butyllithium in diethyl ether; hexane T=-78 - 0°C; 2.5 h; 2: carbon dioxide in diethyl ether; hexane T=-78 - 20°C; 0.166667 h; 3: With ammonium chloride in diethyl ether; hexane; water T=20°C; 0.0833333 h;
参考文献
Schroeder, Gretchen M.; An, Yongmi; Cai, Zhen-Wei; Chen, Xiao-Tao; Clark, Cheryl; Cornelius, Lyndon A. M.; Dai, Jun; Gullo-Brown, Johnni; Gupta, Ashok; Henley, Benjamin; Hunt, John T.; Jeyaseelan, Robert; Kamath, Amrita; Kim, Kyoung; Lippy, Jonathan; Lombardo, Louis J.; Manne, Veeraswamy; Oppenheimer, Simone; Sack, John S.; Schmidt, Robert J.; Shen, Guoxiang; Stefanski, Kevin; Tokarski, John S.; Trainor, George L.; Wautlet, Barri S.; Wei, Donna; Williams, David K.; Zhang, Yingru; Zhang, Yueping; Fargnoli, Joseph; Borzilleri, Robert M.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 5 p. 1251 - 1254
