3,3''-二溴-1,1':3',1''-三联苯合成路线 （共 9 条）
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in water; toluene
Suzuki Coupling; 7.5 h;
参考文献
IDEMITSU KOSAN CO., LTD.
Patent: WO2006/85434 A1, 2006 ;
Location in patent: Page/Page column 41-42 ;
反应条件
1: NaOH, MeOH
2: NaOEt, EtOH
3: aq. NaOH / ethanol / Heating
4: (i) NaBH4, aq. NaOH, (ii) NaHSO4, (iii) Br2, CHCl3
View Scheme
参考文献
Sunshine,N.B.; Woods,G.F.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2517 - 2522
反应条件
1: NaOEt, EtOH
2: aq. NaOH / ethanol / Heating
3: (i) NaBH4, aq. NaOH, (ii) NaHSO4, (iii) Br2, CHCl3
View Scheme
参考文献
Sunshine,N.B.; Woods,G.F.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2517 - 2522
反应条件
1: aq. NaOH / ethanol / Heating
2: (i) NaBH4, aq. NaOH, (ii) NaHSO4, (iii) Br2, CHCl3
View Scheme
参考文献
Sunshine,N.B.; Woods,G.F.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2517 - 2522
反应条件
1: 37 percent / Cu powder / dimethylformamide / 16 h / Heating
2: 98 percent / Fe / benzene / Heating
3: 1) NaNO2, aq. HBr, 2) Cu2Br2, aq. HBr / 1= 0-5 deg C, 2 h, 2) up to 80 deg C
View Scheme
参考文献
Fujioka
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 12 p. 3494 - 3506
反应条件
1: 37 percent / Cu powder / dimethylformamide / 16 h / Heating
2: 98 percent / Fe / benzene / Heating
3: 1) NaNO2, aq. HBr, 2) Cu2Br2, aq. HBr / 1= 0-5 deg C, 2 h, 2) up to 80 deg C
View Scheme
参考文献
Fujioka
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 12 p. 3494 - 3506
反应条件
1: 98 percent / Fe / benzene / Heating
2: 1) NaNO2, aq. HBr, 2) Cu2Br2, aq. HBr / 1= 0-5 deg C, 2 h, 2) up to 80 deg C
View Scheme
参考文献
Fujioka
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 12 p. 3494 - 3506
反应条件
copper(I) bromide; hydrogen bromide; sodium nitrite
1= 0-5 deg C, 2 h, 2) up to 80 deg C; Yield given. Multistep reaction;
参考文献
Fujioka
Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 12 p. 3494 - 3506
反应条件
(i) NaBH4, aq. NaOH, (ii) NaHSO4, (iii) Br2, CHCl3; Multistep reaction;
参考文献
Sunshine,N.B.; Woods,G.F.
Journal of Organic Chemistry, 1963 , vol. 28, p. 2517 - 2522
