(2S)-2-[[[[3,5-双(三氟甲基)苯基]氨基]硫氧代甲基]氨基]- n-3,3-三甲基-n-(苯基甲基)丁酰胺合成路线 (共 1 条)
反应条件
1: tert-butyl (S)-1-(N-benzyl-N-methylcarbamoyl)-2,2-dimethylpropylcarbamate With hydrogenchloride in 1,4-dioxane
T=20°C; 2 h;
2: 3,5-bis(trifluoromethyl)phenyl isothiocyanate With triethylamine in dichloromethane
T=20°C; 4 h; Further stages.;
参考文献
Reisman, Sarah E.; Doyle, Abigail G.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2008 , vol. 130, # 23 p. 7198 - 7199