顺-(+)-5-甲氧基-1-甲基-2-(二正丙基氨基)萘满马来酸合成路线 （共 10 条）
反应条件
1: 71 percent / H2 / 10percent Pd/C / methanol / 760 Torr / Ambient temperature
2: K2CO3 / acetonitrile / 240 h / Ambient temperature
View Scheme
参考文献
Johansson, Anette M.; Arvidsson, Lars-Erik; Hacksell, Uli; Nilsson, J. Lars G.; Svensson, Kjell; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 8 p. 1049 - 1053
反应条件
potassium carbonate in acetonitrile
a) RT, 6 h, b) 85 deg C, 9 d;
参考文献
Johansson, Anette M.; Arvidsson, Lars-Erik; Hacksell, Uli; Nilson, J. Lars G.; Svensson, Kjell; Carlsson, Arvid
Journal of Medicinal Chemistry, 1987 , vol. 30, # 4 p. 602 - 611
反应条件
1.1: various solvent(s)
2.1: p-TSA / toluene
3.1: monoisopropylcamphenylborane / tetrahydrofuran / -20 - -16 °C
3.2: NaOH; 30 percent aq. H2O2
4.1: pyridine
5.1: NaN3 / H2O; dimethylformamide
6.1: LAH / tetrahydrofuran
7.1: Et3N
8.1: LAH / tetrahydrofuran
9.1: Et3N
10.1: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1.1: monoisopropylcamphenylborane / tetrahydrofuran / -20 - -16 °C
1.2: NaOH; 30 percent aq. H2O2
2.1: pyridine
3.1: NaN3 / H2O; dimethylformamide
4.1: LAH / tetrahydrofuran
5.1: Et3N
6.1: LAH / tetrahydrofuran
7.1: Et3N
8.1: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: Et3N
2: LAH / tetrahydrofuran
3: Et3N
4: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: Et3N
2: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: LAH / tetrahydrofuran
2: Et3N
3: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: pyridine
2: NaN3 / H2O; dimethylformamide
3: LAH / tetrahydrofuran
4: Et3N
5: LAH / tetrahydrofuran
6: Et3N
7: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: LAH / tetrahydrofuran
2: Et3N
3: LAH / tetrahydrofuran
4: Et3N
5: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
反应条件
1: NaN3 / H2O; dimethylformamide
2: LAH / tetrahydrofuran
3: Et3N
4: LAH / tetrahydrofuran
5: Et3N
6: LAH / tetrahydrofuran
View Scheme
参考文献
Reddy, N. Laxma; Francesconi, Iris; Bellott, Emile M.
Tetrahedron Asymmetry, 1999 , vol. 10, # 17 p. 3281 - 3283
