(±)-2-氨基-1-丁醇合成路线 （共 59 条）
反应条件
chiral stationary phase including isopropyl-functionalized CF6 in methanol; acetic acid; triethylamine; acetonitrile T=20°C; Purification / work up;
参考文献
Ingole, Pravin G.; Thakare, Neha R.; Kim, Keehong; Bajaj, Hari C.; Singh, Kripal; Lee, Hyungkeun
New Journal of Chemistry, 2013 , vol. 37, # 12 p. 4018 - 4024
反应条件
1: T=140°C; Acylation; 24 h; 2: With penicillin G acylase; Eupergit C in water T=30°C; Hydrolysis; pH=7.8; 0.583333 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Fadnavis; Sharfuddin, Mohd.; Vadivel
Tetrahedron Asymmetry, 1999 , vol. 10, # 23 p. 4495 - 4500
反应条件
sodium carbonate in water 2 h; Ambient temperature;
参考文献
Francalanci, Franco; Cesti, Pietro; Cabri, Walter; Bianchi, Daniele; Martinengo, Tiziano; Foa, Marco
Journal of Organic Chemistry, 1987 , vol. 52, # 23 p. 5079 - 5082
反应条件
1: 2-amino-3-methylpropanol; C10H16N2O2 in acetonitrile T=5°C; 1.5 h; 2: ethyl iodide T=20°C; 6 h;
参考文献
Perez, Eduardo R; Da Silva, Michele Odnicki; Costa, Vanessa C; Rodrigues-Filho, Ubirajara P; Franco, Douglas W
Tetrahedron Letters, 2002 , vol. 43, # 22 p. 4091 - 4093
反应条件
sodium carbonate; benzene
参考文献
Journal of the American Chemical Society, , vol. 66, p. 539
参考文献
Wilkinson,R.G. et al.
Journal of the American Chemical Society, 1961 , vol. 83, p. 2212 - 2213
参考文献
Wilkinson,R.G. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1962 , vol. 5, p. 835 - 845
参考文献
Butula,I.; Karlovic,G.
Justus Liebigs Annalen der Chemie, 1976 , p. 1455 - 1464
反应条件
(i), (ii) LiAlH4, Et2O, THF; Multistep reaction;
参考文献
Kritzyn,A.M. et al.
Doklady Chemistry, 1962 , vol. 145, p. 597 - 600
Doklady Akademii Nauk SSSR, 1962 , vol. 145, p. 332 - 335
反应条件
triethylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Barker, Timothy J.; Jarvo, Elizabeth R.
Angewandte Chemie - International Edition, 2011 , vol. 50, # 36 p. 8325 - 8328
