2-氯-5-硝基苯磺酰胺合成路线 （共 11 条）
反应条件
1: With chlorosulfonic acid T=120°C; 2: With ammonium hydroxide in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
Lori, Franco; Chafouleas, James; De Forni, Davide; Solinas, Antonio; Varga, Zoltán; Greff, Zoltán; Örfi, László; Kéri, György
Patent: US2014/57911 A1, 2014 ;
Location in patent: Paragraph 0389; 0390 ;
反应条件
ammonia in water T=10 - 20°C;
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
1: With hydrogenchloride; sodium nitrite in acetic acid T=-5°C; 2: With sulfur dioxide; copper dichloride in acetic acid 3: With ammonium hydroxide in water T=20°C; 0.5 h;
参考文献
Somers, Fabian; De Tullio; Boverie; Dogne; De Leval; Antoine; Lebrun; Pirotte
Pharmacy and Pharmacology Communications, 2000 , vol. 6, # 2 p. 89 - 95
反应条件
1: With thionyl chloride in N,N-dimethyl-formamide Heating / reflux; 2: With ammonia in tetrahydrofuran; water; N,N-dimethyl-formamide; toluene T=-10°C; 2 h; 3: With hydrogenchloride in tetrahydrofuran; water; N,N-dimethyl-formamide; toluene pH=4; Product distribution / selectivity;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/82725 A1, 2008 ;
Location in patent: Page/Page column 127; 171 ;
反应条件
sulfur dioxide; ammonia; sodium nitrite in water; acetic acid
反应条件
1: T=120°C; 100 h; 2: With ammonia in water T=0 - 25°C; 18 h; Product distribution / selectivity;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/73982 A2, 2008 ;
Location in patent: Page/Page column 68-69 ;
反应条件
1: trichlorophosphate / acetonitrile; isobutyramide / 3 h / Reflux 2: ammonia / water / 1 h / 20 °C View Scheme
反应条件
1: 90 percent / (NH4)2CO3; CuSO4; aq. NH3 / 4 h / 120 °C 2: 70 percent / Na2S2O4; aq. NaOH View Scheme
参考文献
Ismail, Mohamed A.H.; Abou El Ella, Dalal A.; Abouzid, Khaled A.M.; Mahmoud, Amr H.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5647 - 5647
反应条件
palladium 10 on activated carbon; hydrogen in methanol T=50°C; 4 h;
参考文献
Pan, Li; Jiang, Ying; Liu, Zhen; Liu, Xing-Hai; Liu, Zhuo; Wang, Gang; Li, Zheng-Ming; Wang, Di
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 18 - 26
反应条件
1.1: triethylamine / acetonitrile / 20 h / 92 °C / Industry scale
2.1: hydrogen / palladium 10 on activated carbon / ethanol; water; tetrahydrofuran / 43 h / 50 °C / 2844.39 Torr / Industry scale
3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale
4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
5.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale
5.2: 0 °C / Industry scale
View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
