2-(N,N-二异丙氨基)氯乙烷合成路线 （共 19 条）
参考文献
Sahyun
Patent: US2584160 , 1950 ;
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Abbott Labor.
Patent: DE915814 , 1952 ;
反应条件
sodium amide; benzene
参考文献
N.V. Nederl. Combinatie Chem. Ind.
Patent: DE1003744 , 1957 ;
反应条件
1: 67 percent / NaNH2 / toluene / 0.5 h / 80 - 85 °C
2: NaNH2 / 1.) toluene, 100 deg C, 10 min, 2.) toluene, reflux, 45 min
3: 74 percent / 90percent aq. H2SO4 / 2 h / Heating
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参考文献
Yonan; Novotney; Min Woo; Prodan; Hershenson
Journal of Medicinal Chemistry, 1980 , vol. 23, # 10 p. 1102 - 1108
反应条件
sodium amide in toluene
2 h; Heating;
参考文献
Bernhart; Condamine; Demarne; Roncucci; Gagnol; Gautier; Serre
Journal of Medicinal Chemistry, 1983 , vol. 26, # 3 p. 451 - 455
参考文献
Sahyun
Patent: US2584160 , 1950 ;
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Abbott Labor.
Patent: DE915814 , 1952 ;
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 605346/; Multistep reaction;
参考文献
Unterhalt; Thamer
Archiv der Pharmazie, 1976 , vol. 309, # 10 p. 804 - 811
参考文献
Sahyun
Patent: US2584160 , 1950 ;
Full Text Show Details
Abbott Labor.
Patent: DE915814 , 1952 ;
参考文献
Sahyun
Patent: US2584160 , 1950 ;
Full Text Show Details
Abbott Labor.
Patent: DE915814 , 1952 ;
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane; disulfur dichloride in chloroform
T=0°C; 72 h;
2: With formic acid in chloroform
1.5 h; Heating;
参考文献
Konstantinova; Berezin; Rakitin
Russian Chemical Bulletin, 2007 , vol. 56, # 6 p. 1178 - 1183
