4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
1: 17 percent / As2O5, H3PO4 / 1 h / 100 °C
2: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
3: Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: Diazotization
2: copper-powder / 130 - 170 °C
View Scheme
参考文献
Lothrop
Journal of the American Chemical Society, 1942 , vol. 64, p. 1698
反应条件
1: H2 / Raney Ni / ethanol / 1 h / 760 Torr / Ambient temperature
2: 82 percent / aq. SeO2 / ethanol
3: 87 percent / conc. H2SO4, fuming HNO3 / 1 h / Ambient temperature
4: 74 percent / aq. NH4SH / methanol / 2 h / Heating
5: 11 percent / KOH / methanol; H2O / 0.17 h / Heating
6: 81 percent / 2-ethoxy-ethanol; H2O / Heating
View Scheme
参考文献
Grivas, Spiros; Tian, Wei
Acta Chemica Scandinavica, 1992 , vol. 46, # 11 p. 1109 - 1113
反应条件
acetic anhydride
1.5 h; Ambient temperature;
参考文献
Tanaka; Ino; Murakami
Chemical and Pharmaceutical Bulletin, 1981 , vol. 29, # 7 p. 1876 - 1886
反应条件
1: 17 percent / As2O5, H3PO4 / 1 h / 100 °C
2: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
3: 22 percent / Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
sodium chloride; potassium carbonate; trifluoroacetic anhydride in dichloromethane; water; acetone
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US5162318 A1, 1992 ;
反应条件
1: 92 percent / CH2Cl2 / 3 h / Heating
2: 86 percent / NaH / tetrahydrofuran
3: 70 percent / HCl conc.; SnCl2*H2O / ethanol / 4 h / Heating
View Scheme
参考文献
Escolano, Carmen; Jones, Keith
Tetrahedron, 2002 , vol. 58, # 7 p. 1453 - 1464
反应条件
1: 17 percent / As2O5, H3PO4 / 1 h / 100 °C
2: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
3: 65 percent / NEt3 / acetonitrile / Heating
4: 83 percent / LiAlH4 / tetrahydrofuran
5: NaCNBH3 / 24 h / 20 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: acetic acid
2: SnCl2; concentrated aqueous HCl
View Scheme
参考文献
Baker et al.
Journal of the American Chemical Society, 1950 , vol. 72, p. 393
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride in water; acetone
2: With sodium nitrite in water; acetone
0.05 h; Sonication;
3: ethyl vinyl ether Further stages;
参考文献
Chernyak, Natalia; Buchwald, Stephen L.
Journal of the American Chemical Society, 2012 , vol. 134, # 43 p. 18147 - 18147,1
