4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
1: sulphur monochloride / acetic acid / 1) 0-10 deg C, 2) room temperature, 0.5 h, 3) 70 deg C, 5 h, 4) 90 deg C
2: 63 percent / sodium hydroxide, sodium bisulphite / H2O / 5 h / Heating
View Scheme
参考文献
Goswami, Naresh K.; Gupta, R. R.; Jain, S. K.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 4 p. 307 - 309
反应条件
1: 2-nitro-4-methoxy-aniline With sulfuric acid; sodium nitrite in water
T=0 - 5°C;
2: potassium thioacyanate With cobalt(II) chloride in water
T=0 - 50°C;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
Location in patent: Page/Page column 56 ;
WO 2012/003418 A2
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile
6 h; Heating / reflux;
参考文献
INVITROGEN CORPORATION
Patent: WO2008/76524 A2, 2008 ;
Location in patent: Page/Page column 91 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=50°C; 24 h;
参考文献
Kimura; Takase; Hayashi; Tanaka; Ohtsuka; Saeki; Kogushi; Yamada; Fujimori; Saitou; Akasaka
Journal of Medicinal Chemistry, 1993 , vol. 36, # 11 p. 1630 - 1640
反应条件
1: Diazotization
2: alcohol / 150 °C
View Scheme
参考文献
Hodgson; Crook
Journal of the Chemical Society, 1932 , p. 1812,1814
Journal of the Chemical Society, 1933 , p. 825
反应条件
1: 1.) 6 N HCl, NaNO2; 2.) CuCl2 / 1.) H2O, -5 deg C, 1 h; 2.) H2O, 50-55 deg C
2: 78.5 percent / conc. H2SO4 / 7 h / Heating
3: 84.1 percent / hydrogen / 10percent Pd-C / acetic acid / Ambient temperature
4: 1.) 6 N HCl, NaNO2; 2.) NaN3 / 1.) -5 deg C, 1 h; 2.) H2O, r.t.
5: 77 percent / o-dichlorobenzene / 1 h / 160 - 170 °C
6: 88 percent / 10percent aq. NaOH / ethanol / 1 h / Heating
7: 76 percent / SOCl2 / benzene / 0.5 h / Heating
View Scheme
参考文献
Nakashima; Kawashima; Amanuma; Sota; Tanaka; Kameyama
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 11 p. 4271 - 4280
反应条件
1.1: hydrogen bromide; sodium nitrite / water / 2 h / 20 °C
1.2: 0.08 h / 80 °C / Inert atmosphere
2.1: copper / 180 - 210 °C
3.1: triethyl phosphite / 4 h / 170 °C / Inert atmosphere
View Scheme
参考文献
Tsuchiya, Kousuke; Sakaguchi, Kota; Kasuga, Hidemasa; Kawakami, Akira; Taka, Hideo; Kita, Hiroshi; Ogino, Kenji
Polymer, 2010 , vol. 51, # 3 p. 616 - 622
参考文献
Sondhi, Sham M.; Johar, Monika; Singh, Nirupma; Dastidar, Sunanda G.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 1 p. 162 - 167
反应条件
2: diphenyl ether biphenyl mixture
3: aqueous NaOH
4: biphenyl; diphenyl ether
5: phosphoryl chloride
View Scheme
参考文献
Riegel et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1264
反应条件
sulfuric acid; sodium acetate; sodium nitrite
1.) H2O, 0 deg C, 48 h 2.) ethanol, 0 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Coburn; Gala
Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 4 p. 757 - 759
