4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
acetone; calcium carbonate
参考文献
Ismail'skii; Simonow
Zhurnal Obshchei Khimii, 1940 , vol. 10, p. 1580,1582
Chem. Zentralbl., 1941 , vol. 112, # II p. 36
反应条件
bromobenzene
unter Zusatz von Kaliumcarbonat, Kaliumjodid und Kupfer-Pulver auf 180grad;
参考文献
King; King; Muir
Journal of the Chemical Society, 1946 , p. 5,8
反应条件
nitric acid in water
T=20°C;
参考文献
Wyeth
Patent: EP1147083 B1, 2004 ;
Location in patent: Page 48 ;
EP 1147083 B1
反应条件
ammonium cerium (IV) nitrate in water; acetonitrile
T=20°C; 0.333333 h;
参考文献
Chen, Yugang; Ying, Weijiang; Harmata, Michael
Tetrahedron Letters, 2011 , vol. 52, # 4 p. 480 - 482
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride in water
T=80°C; Meerwein method; 0.5 h;
2: With sodium nitrite in water
T=-10 - 0°C; 0.666667 h;
3: furfural With copper dichloride in water; acetone
T=20°C; 12 h;
参考文献
Butin, Alexander V.; Tsiunchik, Fatima A.; Abaev, Vladimir T.; Zavodnik, Valery E.
Synlett, 2008 , # 8 p. 1145 - 1148
反应条件
2: diphenyl ether biphenyl mixture
View Scheme
参考文献
Riegel et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1264
反应条件
hydrogenchloride; tin(ll) chloride; sodium nitrite
Yield given. Multistep reaction;
参考文献
Palomba; Pintore; Boatto; Asproni; Cerri; Pau; Farris
Farmaco, 1996 , vol. 51, # 1 p. 79 - 84
反应条件
1: sodium dithionite / methanol / 0.6 h / 70 °C
2: acetic acid; hydrogen bromide / 24 h / 100 °C / |Inert atmosphere
View Scheme
参考文献
Zhou, Binhua; Li, Baojian; Yi, Wei; Bu, Xianzhang; Ma, Lin
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3759 - 3763
