4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
sulfuric acid in dichloromethane; water; glycerol
参考文献
Wyeth
Patent: US2003/32645 A1, 2003 ;
US 20030032645 A1
反应条件
diarsenic pentoxide; phosphoric acid T=100°C; 1 h;
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
sulfuric acid; orthoarsenic acid T=105 - 123°C;
参考文献
McChesney; Sarangan; Hufford
Journal of Pharmaceutical Sciences, 1984 , vol. 73, # 12 p. 1854 - 1856
参考文献
Yale; Bernstein
Journal of the American Chemical Society, 1948 , vol. 70, p. 254
反应条件
potassium hydroxide; sodium hypochlorite in methanol; water
参考文献
Monge, Antonio; Palop, Juan A.; Cerain, Adela Lopez de; Senador, Virginia; Martinez-Crespo, Francisko J.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1786 - 1792
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; 0.75 h; 2: With sulfur dioxide; acetic acid; copper dichloride 1.5 h;
参考文献
Lebegue, Nicolas; Gallet, Sebastien; Flouquet, Nathalie; Carato, Pascal; Pfeiffer, Bruno; Renard, Pierre; Leonce, Stephane; Pierre, Alain; Chavatte, Philippe; Berthelot, Pascal
Journal of Medicinal Chemistry, 2005 , vol. 48, # 23 p. 7363 - 7373
反应条件
1: nickel (II)-chloride; water 2: acetic acid; aqueous sulfuric acid View Scheme
参考文献
Journal of the Chemical Society, , p. 1034,1037
参考文献
Chopra, Sidharth; Koolpe, Gary A.; Tambo-Ong, Arlyn A.; Matsuyama, Karen N.; Ryan, Kenneth J.; Tran, Tran B.; Doppalapudi, Rupa S.; Riccio, Edward S.; Iyer, Lalitha V.; Green, Carol E.; Wan, Baojie; Franzblau, Scott G.; Madrid, Peter B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 13 p. 6047 - 6060
反应条件
1: HCl / 100 °C 2: aq. NaOH / 1 h / 100 °C View Scheme
参考文献
Hay, Michael P.; Gamage, Swarna A.; Kovacs, Mary S.; Pruijn, Frederik B.; Anderson, Robert F.; Patterson, Adam V.; Wilson, William R.; Brown, J. Martin; Denny, William A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 1 p. 169 - 182
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C;
参考文献
Jean-Claude, Bertrand J.; Just, George
Heterocycles, 1998 , vol. 48, # 7 p. 1347 - 1363
