4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in water; toluene T=20°C; Methylation;
参考文献
Voskresensky; Makosza
Synthetic Communications, 2000 , vol. 30, # 19 p. 3523 - 3526
反应条件
1: 76.1 g / trifluoroacetic acid / 96 h / Ambient temperature 2: 1.) NaOH, 2.) H2O / 1.) acetone, reflux, 10 min, 2.) reflux, 0.5 h View Scheme
参考文献
Katritzky, Alan R.; Rachwal, Stanislaw; Ollmann, Richard
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 775 - 780
反应条件
1: AcOH 2: BiCl3; NaBH4 / ethanol View Scheme
参考文献
Guillon, Jean; Grellier, Philippe; Labaied, Mehdi; Sonnet, Pascal; Leger, Jean-Michel; Deprez-Poulain, Rebecca; Forfar-Bares, Isabelle; Dallemagne, Patrick; Lemaitre, Nicolas; Pehourcq, Fabienne; Rochette, Jacques; Sergheraert, Christian; Jarry, Christian
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1997 - 2009
反应条件
1: With hydrogenchloride; sodium nitrite T=0°C; 2: With potassium iodide
参考文献
Wetzel, Alexander; Gagosz, Fabien
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7354 - 7358
反应条件
potassium iodide; sodium nitrite in hydrogenchloride; water
参考文献
Commissariat a l'Energie Atomique
Patent: US4795579 A1, 1989 ;
反应条件
hydrogen bromide; sodium nitrite in 1,4-dioxane; water T=23°C; 36 h;
参考文献
Rudisill; Stille
Journal of Organic Chemistry, 1989 , vol. 54, # 25 p. 5856 - 5866
反应条件
1: Raney nickel; benzene / Hydrogenation 2: sodium acetate; aqueous acetic acid View Scheme
参考文献
Tian, Zhidan; Tian, Baozhu; Zhang, Jinlong
Dyes and Pigments, 2013 , vol. 99, # 3 p. 1132 - 1136
反应条件
1.1: sodium nitrite; sulfuric acid / water / 0 - 5 °C 1.2: 0 - 50 °C 2.1: lithium aluminium tetrahydride / benzene; diethyl ether / Cooling; Reflux; Inert atmosphere 2.2: pH 6 3.1: boric acid / 6 h / Reflux 4.1: hydrogen iodide / 5 h / Reflux View Scheme
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL; JIN, Jian; ROTH, Bryan; FRYE, Stephen
Patent: WO2012/3418 A2, 2012 ;
WO 2012/003418 A2
反应条件
1: Raney nickel; benzene / Hydrogenation 2: sodium acetate; aqueous acetic acid 3: platinum; benzene / 3677.5 Torr / Hydrogenation View Scheme
参考文献
Cavagnol; Wiselogle
Journal of the American Chemical Society, 1947 , vol. 69, p. 795,796
反应条件
1: 1.) HNO2 2: 69 percent / 47percent HBr / H2O / 8 h / 120 °C 3: 81 percent / K2CO3 / dimethylformamide / Ambient temperature View Scheme
参考文献
Shigyo; Sato; Shibuya; Takahashi; Yamaguchi; Sonoki; Ohta
Chemical and Pharmaceutical Bulletin, 1993 , vol. 41, # 9 p. 1573 - 1582
