4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
1.1: NaNO2; HCl / H2O / 0.5 h / 0 °C 1.2: NaCN / H2O / 1 h / 20 °C 2.1: 100 percent / SnCl2; AcOH / 1,2-dimethoxy-ethane; ethanol / 3 h / 65 °C 3.1: NaNO2; HCl / H2O / 0.5 h / 0 °C 3.2: 61 percent / KI / H2O / 0 - 20 °C 4.1: 16 percent / triethylamine; palladium bis(dibenzylideneacetone) / dimethylformamide; H2O / 48 h / 130 °C View Scheme
参考文献
Pletnev, Alexandre A.; Tian, Qingping; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9276 - 9287
反应条件
1: 82 percent / cc. H2SO4, isoamyl nitrite / ethanol / 1 h / 0 °C
2: 55 percent / 0.5M HCl, LiCl / CuCl / H2O; various solvent(s) / 5 deg C, 3.5 h. then 20 deg C, 4 h.
3: 95 percent / H2 / Raney-Ni / ethyl acetate / 18 h
View Scheme
参考文献
Cardwell, Kevin; Hewitt, Brian; Magnus, Philip
Tetrahedron Letters, 1987 , vol. 28, # 29 p. 3303 - 3306
反应条件
1: 53 percent / Copper bronze, K2CO3 / I2 / 24 h / 120 °C
2: Hydrazine hydrate (98percent) / Raney Ni / aq. ethanol / 1 h / Heating
3: 94 percent / 1.) aqueous NaNO2 / acetic acid; H2O / 1.) 0 deg C, 2.) 2 h, 0 deg C bis room temp.
4: 62 percent / acetone; methanol / 500 °C
View Scheme
参考文献
Miller; Stowell
Journal of Organic Chemistry, 1983 , vol. 48, # 6 p. 886 - 888
反应条件
sodium perchlorate in acetonitrile
Oxidation; Electrochemical reaction; Product distribution;
参考文献
Greci, Lucedio; Tommasi, Giampaolo; Astolfi, Paola; Petrucci, Rita; Marrosu, Giancarlo; Trazza, Antonio; Sgarabotto, Paolo; Righi, Lara
Journal of the Chemical Society. Perkin Transactions 2, 2000 , # 8 p. 1749 - 1755
反应条件
diarsenic pentoxide; sulfuric acid; water
参考文献
Jain, Rahul; Jain, Sanjay; Gupta, R C; Anand, Nitya; Dutta, G P; Puri, S K
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, p. 251 - 254
反应条件
diarsenic pentoxide; sulfuric acid; water
参考文献
Campbell et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1556,1558
Journal of the American Chemical Society, 1947 , vol. 69, p. 1465
参考文献
Campbell et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1556,1558
Journal of the American Chemical Society, 1947 , vol. 69, p. 1465
反应条件
1: 17 percent / As2O5, H3PO4 / 1 h / 100 °C
2: 100 percent / H2 / Raney-Ni / 1 h / 20 °C / 2585.74 Torr
3: Et3N / 6 h / 150 °C
View Scheme
参考文献
Armer, Richard E.; Barlow, Jacqueline S.; Chopra, Narinder; Dutton, Christopher J.; Greenway, David H.J.; Greenwood, Sean D.W.; Lad, Nita; Shaw, Jonothan; Thompson, Adrian P.; Thong, Kam-Wah; Tommasini, Ivan
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 16 p. 2425 - 2430
反应条件
1: aqueous H2SO4 / Diazotization.Erhitzen der Diazoniumsalz-Loesung mit NaBr und CuSO4
2: sodium carbonate; copper; 1-methyl-cyclohexanol-(4)
3: phosphoryl chloride
View Scheme
参考文献
Samant
Chemische Berichte, 1942 , vol. 75, p. 1008,1014
反应条件
1: 76 percent / pyridine / 2 h / Ambient temperature
2: 89 percent / sodium hydroxide / H2O / 7.45 h / Heating
3: 92 percent / propionic acid, sulfuric acid / 1.5 h / 95 °C
View Scheme
参考文献
Nicolai, Eric; Goyard, Joel; Benchetrit, Thierry; Teulon, Jean-Marie; Caussade, Francois; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1176 - 1187
