4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 17 h / 0 - 20 °C / |Inert atmosphere
2: potassium carbonate / dimethyl sulfoxide / 17 h / 60 °C
View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
反应条件
1: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / dichloromethane / 17 h / 0 - 20 °C / |Inert atmosphere
2: potassium carbonate / dimethyl sulfoxide / 17 h / 60 °C
3: palladium(II) oxide hydrate; hydrogen / methanol / 17 h / 20 °C
View Scheme
参考文献
Skouta, Rachid; Dixon, Scott J.; Wang, Jianlin; Dunn, Denise E.; Orman, Marina; Shimada, Kenichi; Rosenberg, Paul A.; Lo, Donald C.; Weinberg, Joel M.; Linkermann, Andreas; Stockwell, Brent R.
Journal of the American Chemical Society, 2014 , vol. 136, # 12 p. 4551 - 4556
反应条件
1: Cu, N-methylmorpholine / 3-methyl-butan-1-ol / 18 h / Heating
2: H2 / 5 percent Pd/C / methanol / 3 h
View Scheme
参考文献
Palmer, Brian D.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 27 p. 5457 - 5465
反应条件
sulfuric acid
18 h; Heating;
参考文献
Van Der Aar, Ellen M.; De Groot, Marcel J.; Bouwman, Tialda; Bijloo, Greetje J.; Commandeur, Jan N. M.; Vermeulen, Nico P. E.
Chemical Research in Toxicology, 1997 , vol. 10, # 4 p. 439 - 449
反应条件
1: 4-chloro-3-nitro-benzoic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in dichloromethane
0.0833333 h; ice bath;
2: N-butylamine in dichloromethane
T=20°C; 0.25 h;
参考文献
Freeman, Adam W.; Urvoy, Marie; Criswell, Megan E.
Journal of Organic Chemistry, 2005 , vol. 70, # 13 p. 5014 - 5019
反应条件
1: NaN3 / dimethylsulfoxide
2: SOCl2 / toluene
View Scheme
参考文献
Boulton,A.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 971 - 976
反应条件
1: Cl(CO)2Cl, DMF / CH2Cl2 / Ambient temperature
2: AlCl3 / Ambient temperature
3: Fe, glacial AcOH / 80 °C
View Scheme
参考文献
Parlow, John J.; Mischke, Deborah A.; Woodard, Scott S.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5908 - 5919
反应条件
pyridine in cyclohexanol; benzene
参考文献
Eli Lilly and Company
Patent: US4018790 A1, 1977 ;
参考文献
Eli Lilly and Company
Patent: US4008243 A1, 1977 ;
反应条件
triethylamine in ethyl acetate; N,N-dimethyl-formamide
参考文献
Shiseido Co., Ltd.
Patent: US6204264 B1, 2001 ;
