4-氯-3-硝基苯甲酸合成路线 （共 122 条）
参考文献
Journal of the Chemical Society, , vol. 127, p. 2649
反应条件
1.1: 25 - 55 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 1.25 h / 25 - 80 °C 2.2: 1 h View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; SINGH, Ramesh Chandra; RAVAL, Jigar Mukundbhai
Patent: WO2013/111163 A2, 2013 ;
反应条件
thionyl chloride in dichloromethane; N,N-dimethyl-formamide Heating;
参考文献
Berrada, Amal; Cavelier, Florine; Jacquier, Robert; Verducci, Jean
Bulletin de la Societe Chimique de France, 1989 , # 4 p. 511 - 514
参考文献
Eli Lilly and Company
Patent: US4008243 A1, 1977 ;
反应条件
in 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide
参考文献
Zeneca Limited
Patent: US5451594 A1, 1995 ;
反应条件
sulfuric acid in ethanol T=90°C; (electrochemical reduction);
参考文献
le Guyader,M.
Bulletin de la Societe Chimique de France, 1966 , p. 1848 - 1858
反应条件
borane-THF; boron trifluoride diethyl etherate in tetrahydrofuran T=20°C; 18 h;
参考文献
Marchand, Pascal; Antoine, Maud; Baut, Guillaume Le; Czech, Michael; Baasner, Silke; Guenther, Eckhard
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 18 p. 6715 - 6727
反应条件
1: Cl(CO)2Cl, DMF / CH2Cl2 / Ambient temperature 2: AlCl3 / Ambient temperature View Scheme
参考文献
Parlow, John J.; Mischke, Deborah A.; Woodard, Scott S.
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 5908 - 5919
反应条件
in water T=100°C; 14 h;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0291 ;
反应条件
methylamine in water
参考文献
Church, Timothy J.; Cutshall, Neil Scott; Gangloff, Anthony R.; Jenkins, Thomas E.; Linsell, Martin S.; Litvak, Joane; Rice, Kenneth D.; Spencer, Jeffrey R.; Wang, Vivian R.
Patent: US2001/53779 A1, 2001 ;
