4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
1: HCl 2: 79 percent / dimethylformamide / 80 °C 3: 86 percent / H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
water; sodium hydroxide T=100°C;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
Location in patent: Paragraph 0266 ;
反应条件
sodium azide in dimethyl sulfoxide
参考文献
Boulton,A.J. et al.
Journal of the Chemical Society [Section] C: Organic, 1966 , p. 971 - 976
反应条件
1: water / 14 h / 100 °C 2: hydrogen; palladium on activated charcoal / methanol / 48 h / 20 °C 3: water / 85 °C View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: (i) SOCl2, (ii) /BRN= 1236623/, AlCl3 2: NH3 3: H2, aq. HCl / Pt View Scheme
参考文献
Raeymackers; Van Gelder; Roevens; Janssen
Arzneimittel-Forschung/Drug Research, 1978 , vol. 28, # 4 p. 586 - 594
反应条件
1: aqueous NH3 / 170 °C 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Org. Poluprod. Krasit.Chem.Abstr., , # 1 p. 231,233
Org. Poluprod. Krasit.Chem.Abstr., , p. 18748
反应条件
sodium hydroxide; zinc in formic acid; water
参考文献
Davies, David Thomas; Jones, Graham Elgin; Peightfoot, Andrew; Markwell, Roger Edward; Pearson, Neil David
Patent: US2004/38998 A1, 2004 ;
反应条件
1: 4-chloro-3-nitro-benzoic acid With sodium sulfide; sodium hydroxide in water 24 h; Heating / reflux; 2: formic acid With zinc 6 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM P.L.C.
Patent: WO2003/87098 A1, 2003 ;
Location in patent: Page/Page column 67 ;
反应条件
1: water / 14 h / 100 °C 2: hydrogen; palladium on activated charcoal / methanol / 48 h / 20 °C View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
thionyl chloride in tetrahydrofuran; 1,2-dichloro-ethane; N,N-dimethyl-formamide
参考文献
Cancer Research Campaign Technology Limited
Patent: US5985909 A1, 1999 ;
