4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
1: HCl 2: 79 percent / dimethylformamide / 80 °C View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
1: water; sodium hydroxide / 100 °C 2: hydrogen; palladium on activated charcoal / methanol / 20 °C / 760.05 Torr 3: 3 h / |Reflux View Scheme
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Li; HU, Yuandong; YU, Rong; HU, Wei; ZHAO, Na; PENG, Yong; LUO, Hong; HAN, Yongxin
Patent: WO2013/97773 A1, 2013 ;
反应条件
1: With N,N-dimethyl-formamide in thionyl chloride 1 h; Heating / reflux; 2: With ammonia in tetrahydrofuran; thionyl chloride; water 1 h;
参考文献
Shionogi and Co., Ltd.
Patent: WO2005/121132 A1, 2005 ;
Location in patent: Page/Page column 249-250 ;
反应条件
thionyl chloride in ethanol; water; acetonitrile
参考文献
S R I International
Patent: US5175287 A1, 1992 ;
参考文献
Janssen Pharmaceutica N.V.
Patent: US4943574 A1, 1990 ;
反应条件
sulfuric acid in ethanol
参考文献
Japan Tobacco Inc.
Patent: US2003/50320 A1, 2003 ;
US 20030050320 A1
反应条件
potassium carbonate in N,N-dimethyl-formamide T=60°C; 3 h;
参考文献
Dainippon Sumitomo Pharma Co., Ltd.
Patent: EP1726587 A1, 2006 ;
Location in patent: Page/Page column 47 ;
反应条件
sulfuric acid 4 h; Heating;
参考文献
Aguirre, Gabriela; Boiani, Mariana; Cerecetto, Hugo; Gerpe, Alejandra; Gonzalez, Mercedes; Sainz, Yolanda Fernandez; Denicola, Ana; De Ocariz, Carmen Ochoa; Nogal, Juan Jose; Montero, David; Escario, Jose Antonio
Archiv der Pharmazie, 2004 , vol. 337, # 5 p. 259 - 270
反应条件
4-methyl-morpholine; hydrogenchloride in 3-methyl-1-butanol; ethyl acetate
参考文献
Warner-Lambert Company
Patent: US5990146 A1, 1999 ;
US 5990146 A
反应条件
1: HCl 2: dimethylformamide / 80 °C 3: H2 / Pd/C / ethanol / 2068.59 Torr View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
