1: diethyl sulphate; 2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)benzoic acid in N,N-dimethyl-formamide T=60°C; Alkylation; 2: With HOBt-6-carboxamidomethyl polystyrene; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate in N,N-dimethyl-formamide Condensation; 3: 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide With isocyanate resin in tetrahydrofuran Acylation;

1.1: dimethylformamide / 60 °C 1.2: polymer-supported HOBt; PyBrOP / dimethylformamide 1.3: isocyanate resin / tetrahydrofuran 2.1: 100 percent / NaOEt / ethanol / 0.17 h / 120 °C / microwave irradiation View Scheme

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane 2: sodium hydroxide / diethylene glycol 3: potassium carbonate / acetone / Reflux View Scheme

1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane 2: sodium hydroxide / diethylene glycol 3: potassium carbonate; potassium iodide / acetone / 4 h / 20 °C / Inert atmosphere; Reflux View Scheme